Repeated out-of-Africa expansions of Helicobacter pylori driven by replacement of deleterious mutations.

ABSTRACT: Helicobacter pylori lives in the human stomach and has a population structure resembling that of its host. However, H. pylori from Europe and the Middle East trace substantially more ancestry from modern African populations than the humans that carry them. Here, we use a collection of Afro-Eurasian H. pylori genomes to show that this African ancestry is due to at least three distinct admixture events. H. pylori from East Asia, which have undergone little admixture, have accumulated many more non-synonymous mutations than African strains. European and Middle Eastern bacteria have elevated African ancestry at the sites of these mutations, implying selection to remove them during admixture. Simulations show that population fitness can be restored after bottlenecks by migration and subsequent

SUBMITTER: Thorpe HA 

PROVIDER: S-EPMC9652371 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature