IL-4 gene polymorphisms and their association with nematodes infection in Pakistani population.

ABSTRACT:

Background

Interleukin-4 (IL-4) plays a central role in the humoral immune defense against nematode parasite infections, inducing IgE switch and regulation of worm expulsion from the intestines. The present study aimed to investigate the polymorphisms in IL-4 gene and their association with socio-demographic and environmental factors among patients with gastrointestinal complaints.

Method

The screened population comprised 305 patients aged 3-50 years from Rawalpindi and Jhelum districts of Pakistan. A well-prepared questionnaire was administered to collect data on socio-demographic and environmental factors. The data were analyzed by using multiple logistic regression models. Molecular analysis was done on 88 confirmed cases passing worms and eggs in stool by using PCR to am

SUBMITTER: Afshan K 

PROVIDER: S-EPMC9652695 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature