A Novel Antimicrobial Peptide Spampcin_56-86 from Scylla paramamosain Exerting Rapid Bactericidal and Anti-Biofilm Activity In Vitro and Anti-Infection In Vivo.

ABSTRACT: The abuse of antibiotics leads to the increase of bacterial resistance, which seriously threatens human health. Therefore, there is an urgent need to find effective alternatives to antibiotics, and antimicrobial peptides (AMPs) are the most promising antibacterial agents and have received extensive attention. In this study, a novel potential AMP was identified from the marine invertebrate Scylla paramamosain and named Spampcin. After bioinformatics analysis and AMP database prediction, four truncated peptides (Spa31, Spa22, Spa20 and Spa14) derived from Spampcin were screened, all of which showed potent antimicrobial activity with different antibacterial spectrum. Among them, Spampcin_56-86 (Spa31 for short) exhibited strong bactericidal activity against a variety of clini

SUBMITTER: Jiang M 

PROVIDER: S-EPMC9653689 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature