Dataset Information

Personality Traits Predict Life Satisfaction in Coronary Heart Disease (CHD) Patients.

ABSTRACT:

Objectives

The objective of the current study is to establish the association between Big Five personality traits and life satisfaction in coronary heart disease (CHD) patients.

Methods

The current study analyzed data from 566 patients with CHD with a mean age of 63.00 ± 15.23 years old (61.13% males) and 3018 healthy controls (63.95% females) with a mean age of 63.85 (S.D. = 9.59) years old from the UKHLS. A train-and-test approach accompanied by one-sample t-tests was used to analyze the differences in personality traits and life satisfaction between CHD patients and healthy controls while controlling for potential confounders. Two multiple regression models were applied to analyze the associations between personality traits and life satisfaction in CHD patients and healthy controls, respectively.

Results

The current study found that CHD patients have lower conscientiousness scores than healthy controls. Moreover, neuroticism was negatively related to life satisfaction, and agreeableness, conscientiousness, and extraversion were positively related to life satisfaction in healthy controls. However, only neuroticism and agreeableness were related to life satisfaction in CHD patients.

Conclusion

Health professionals and clinicians should utilize findings from the current study to make customized interventions based on CHD patients' personality traits to gain better well-being outcomes such as life satisfaction.

SUBMITTER: Kang W

PROVIDER: S-EPMC9654296 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature

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Publications

Personality Traits Predict Life Satisfaction in Coronary Heart Disease (CHD) Patients.

Kang Weixi W

Journal of clinical medicine 20221026 21

<h4>Objectives</h4>The objective of the current study is to establish the association between Big Five personality traits and life satisfaction in coronary heart disease (CHD) patients.<h4>Methods</h4>The current study analyzed data from 566 patients with CHD with a mean age of 63.00 ± 15.23 years old (61.13% males) and 3018 healthy controls (63.95% females) with a mean age of 63.85 (S.D. = 9.59) years old from the UKHLS. A train-and-test approach accompanied by one-sample t-tests was used to an ...[more]

PMID: 36362545

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Project description:BackgroundCoronary heart disease (CHD) and its major risk factor hypertension have both been associated with altered activity of the hypothalamus-pituitary-adrenal (HPA)-axis but the biological mechanisms underlying prospective associations with adverse disease outcomes are unclear. We investigated diurnal HPA-axis activity in CHD-patients, hypertensive (HT) and healthy normotensive men (NT) and tested for prospective associations with biological CHD risk factors.MethodsEighty-three male CHD-patients, 54 HT and 54 NT men repeatedly measured salivary cortisol over two consecutive days. Prospective CHD risk was assessed by changes between baseline and follow-up in the prothrombotic factors D-dimer and fibrinogen, the pro-inflammatory measures interleukin (IL)-6, tumor necrosis factor-alpha (TNF-α), and acute phase protein C-reactive protein (CRP), as well as blood lipids in terms of total cholesterol (tChol)/high-density-lipoprotein cholesterol (HDL)-ratio. We aggregated coagulation and inflammatory measures to respective indices.ResultsThe groups differed in repeated daytime cortisol (dayCort) secretion (p=.005,η2 p=.03,f=0.18) and cortisol awakening response (CAR) (p=.006,η2 p=.03,f=0.18), with similarly lower overall dayCort and CAR in CHD-patients and HT, as compared to NT. The groups differed further in cortisol at awakening (p=.015,η2 p=.04,f=0.20) with highest levels in HT (p´s≤.050), and in diurnal slope between waking and evening cortisol (p=.033,η2 p=.04,f=0.20) with steepest slopes in HT (p´s≤.039), although in part not independent of confounders. Lower aggregated dayCort and CAR in terms of area-under-the-curve (AUC) independently predicted increases in future overall CHD risk (AUCdayCort: p=.021,η2 p=.10,f=0.33;AUCCAR: p=.028,η2 p=.09,f=0.31) 3.00 ± 0.06(SEM) years later, with risk prediction most pronounced in fibrinogen (AUCdayCort: p=.017,ΔR 2= 0.12;AUCCAR: p=.082).ConclusionWe found evidence for an HPA-axis hypoactivity in CHD and HT with lower diurnal HPA-axis activity predicting increases in cardiovascular risk as evidenced by increases in circulating levels of biomarkers of atherothrombotic risk. Down-regulation of basal HPA-axis activity may contribute to the pathogenesis of atherosclerosis and thrombosis in CHD via effects on coagulation.

Dataset Information

Personality Traits Predict Life Satisfaction in Coronary Heart Disease (CHD) Patients.

Objectives

Methods

Results

Conclusion

Publications

Personality Traits Predict Life Satisfaction in Coronary Heart Disease (CHD) Patients.

Similar Datasets

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