Single-Cell Sequencing in Rheumatic Diseases: New Insights from the Perspective of the Cell Type.

ABSTRACT: Rheumatic diseases are a group of highly heterogeneous autoimmune and inflammatory disorders involving multiple systems. Dysfunction of immune and non-immune cells participates in the complex pathogenesis of rheumatic diseases. Therefore, studies on the abnormal activation of cell subtypes provided a specific basis for understanding the pathogenesis of rheumatic diseases, which promoted the accuracy of disease diagnosis and the effectiveness of various treatments. However, there was still a far way to achieve individualized precision medicine as the result of heterogeneity among cell subtypes. To obtain the biological information of cell subtypes, single-cell sequencing, a cutting-edge technology, is used for analyzing their genomes, transcriptomes, epigenetics, and proteomics. Novel resul

SUBMITTER: Ding L 

PROVIDER: S-EPMC9662270 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature