Genome characterization, phylogenomic assessment and spatio-temporal dynamics study of highly mutated BA variants from India.

ABSTRACT:

Purpose

The emergence of highly mutated and transmissible BA variants has caused an unprecedented surge in COVID-19 infections worldwide. Thorough analysis of its genome structure and phylogenomic evolutionary details will serve as scientific reference for future research.

Method

Here, we have analyzed the BA variants from India using whole-genome sequencing, spike protein mutation study, spatio-temporal surveillance, phylogenomic assessment and epitope mapping.

Results

The predominance of BA.2/BA.2-like was observed in India during COVID-19 third wave. Genome analysis and mutation study highlighted the existence of 2128 amino acid changes within BA as compared to NC_045512.2. Presence of 23 unknown mutation sites (spanning region 61-831) were observed among the India

SUBMITTER: Sarkar P 

PROVIDER: S-EPMC9664238 | biostudies-literature | 2023 May-Jun

REPOSITORIES: biostudies-literature