Long-term Cognitive Trajectory After Total Joint Arthroplasty.

ABSTRACT:

Importance

Individuals with total joint arthroplasty (TJA) have long-term exposure to metal-containing implants; however, whether long-term exposure to artificial implants is associated with cognitive function is unknown.

Objective

To compare long-term cognitive trajectories in individuals with and without TJA.

Design, setting, and participants

This population-based cohort study assessed serial cognitive evaluations of 5550 participants (≥50 years of age) from the Mayo Clinic Study of Aging between November 1, 2004, and December 31, 2020.

Exposures

Total joint arthroplasty of the hip or the knee.

Main outcomes and measures

Linear mixed-effects models were used to compare the annualized rate of change in global and domain-specific cognitive scores in part

SUBMITTER: Vassilaki M 

PROVIDER: S-EPMC9664257 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature