Anxiety and anhedonia in depression: Associations with neuroticism and cognitive control.

ABSTRACT:

Background

Despite the fact that higher levels of anxiety and anhedonia in Major Depressive Disorder (MDD) are linked to poorer treatment outcomes, mechanisms contributing to these clinical presentations remain unclear. Neuroticism, impaired cognitive control, and blunted reward learning may be critical processes involved in MDD and may help to explain symptoms of anxiety and anhedonia.

Methods

Using baseline data from patients with early-onset MDD (N = 296) in the Establishing Moderators and Biosignatures of Antidepressant Response in Clinical Care (EMBARC) trial, we conducted a path analysis to model relationships between neuroticism, cognitive control, and reward learning to levels of anxiety and anhedonia.

Results

Neuroticism was positively associated with both an

SUBMITTER: Liao A 

PROVIDER: S-EPMC9667857 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature