Predictors of large cell transformation in patients with Sezary Syndrome-A retrospective analysis.

ABSTRACT:

Background

Large cell transformation (LCT) of Sezary Syndrome (SS) is a rare phenomenon. To date, there are no rigorous studies identifying risk factors for its development.

Objectives

Here, we seek to characterize the clinicopathologic risk factors that predispose patients with SS to develop LCT.

Methods

We retrospectively evaluated all SS patient records available in the Michigan Medicine Cancer Registry from 2010-2021. Clinical and pathologic variables were compared between groups. The Kaplan-Meier method and log-rank test were used to assess overall survival.

Results

Of 28 SS patients identified, eight patients experienced LCT, and 20 did not (NLCT). Peak lactate dehydrogenase (LDH) before LCT (p = 0.0012), maximum total body surface area (TBSA) involvement

SUBMITTER: Jairath NK 

PROVIDER: S-EPMC9668185 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature