Total Synthesis and Monoamine Oxidase Inhibitory Activities of (±)-Entonalactam A and Its Derivatives.

ABSTRACT: The first total synthesis of isoindolinone (±)-entonalactam A (6), originally obtained from the fungus Entonaema sp., was achieved in 14 steps from commercially available 5-bromovanillin via benzophenone intermediates. Isoindolinone, phthalide, and benzophenone analogues of natural products were also synthesized. The monoamine oxidase (MAO) A and B inhibitory activities were tested. The isoindolinone derivative 30 exhibited inhibition of both MAO-A and -B (IC₅₀ = 17.8 and 15.8 μM, respectively).

SUBMITTER: Kamauchi H 

PROVIDER: S-EPMC9670909 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature