Dataset Information
Total Synthesis and Monoamine Oxidase Inhibitory Activities of (±)-Entonalactam A and Its Derivatives.
Ontology highlight
ABSTRACT:
SUBMITTER: Kamauchi H
PROVIDER: S-EPMC9670909 | biostudies-literature | 2022 Nov
REPOSITORIES: biostudies-literature
Publications
Total Synthesis and Monoamine Oxidase Inhibitory Activities of (±)-Entonalactam A and Its Derivatives.
ACS omega 20221104 45
The first total synthesis of isoindolinone (±)-entonalactam A (<b>6</b>), originally obtained from the fungus <i>Entonaema</i> sp., was achieved in 14 steps from commercially available 5-bromovanillin via benzophenone intermediates. Isoindolinone, phthalide, and benzophenone analogues of natural products were also synthesized. The monoamine oxidase (MAO) A and B inhibitory activities were tested. The isoindolinone derivative <b>30</b> exhibited inhibition of both MAO-A and -B (IC<sub>50</sub> = ...[more]