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Circadian transcriptional pathway atlas highlights a proteasome switch in intermittent fasting.


ABSTRACT: While intermittent fasting is a safe strategy to benefit health, it remains unclear whether a "timer" exists in vivo to record fasting duration and trigger a transcriptional switch. Here, we map a circadian transcriptional pathway atlas from 600 samples across four metabolic tissues of mice under five feeding regimens. Results show that 95.6% of detected canonical pathways are rhythmic in a tissue-specific and feeding-regimen-specific manner, while only less than 25% of them induce changes in transcriptional function. Fasting for 16 h initiates a circadian resonance of 43 pathways in the liver, and the resonance punctually switches following refeeding. The hepatic proteasome coordinates the resonance, and most genes encoding proteasome subunits display a 16-h fasting-dependent transcriptional switch. These findings indicate that the hepatic proteasome may serve as a fasting timer and a coordinator of pathway transcriptional resonance, which provide a target for revealing the underlying mechanism of intermittent fasting.

SUBMITTER: Wei F 

PROVIDER: S-EPMC9671760 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature

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Circadian transcriptional pathway atlas highlights a proteasome switch in intermittent fasting.

Wei Fang F   Gong Lijun L   Lu Siyu S   Zhou Yiming Y   Liu Li L   Duan Zhigui Z   Xiang Rong R   Gonzalez Frank J FJ   Li Guolin G  

Cell reports 20221001 4


While intermittent fasting is a safe strategy to benefit health, it remains unclear whether a "timer" exists in vivo to record fasting duration and trigger a transcriptional switch. Here, we map a circadian transcriptional pathway atlas from 600 samples across four metabolic tissues of mice under five feeding regimens. Results show that 95.6% of detected canonical pathways are rhythmic in a tissue-specific and feeding-regimen-specific manner, while only less than 25% of them induce changes in tr  ...[more]

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