Ontology highlight
ABSTRACT:
SUBMITTER: Wei F
PROVIDER: S-EPMC9671760 | biostudies-literature | 2022 Oct
REPOSITORIES: biostudies-literature
Wei Fang F Gong Lijun L Lu Siyu S Zhou Yiming Y Liu Li L Duan Zhigui Z Xiang Rong R Gonzalez Frank J FJ Li Guolin G
Cell reports 20221001 4
While intermittent fasting is a safe strategy to benefit health, it remains unclear whether a "timer" exists in vivo to record fasting duration and trigger a transcriptional switch. Here, we map a circadian transcriptional pathway atlas from 600 samples across four metabolic tissues of mice under five feeding regimens. Results show that 95.6% of detected canonical pathways are rhythmic in a tissue-specific and feeding-regimen-specific manner, while only less than 25% of them induce changes in tr ...[more]