Metformin inhibits cardiometabolic syndrome associated cognitive deficits in high fat diet rats.

ABSTRACT:

Objectives

Glucose intolerance and insulin resistance are hallmarks of metabolic syndrome and lead to Alzheimer's disease (AD). The purpose of this study is to elucidate the neuroprotective effect of metformin through insulin regulation with cardiometabolic and neurotransmitter metabolic enzyme regulation in high-fat, high-sucrose diet and streptozotocin (HFHS-STZ)-induced rats.

Methods

Male Wistar rats were treated with metformin (180 mg/kg and 360 mg/kg). STZ (35 mg/kg i.p.) injection was performed on the 14th day of 42 days of HFHS diet treatment. Brain neurotransmitter metabolic enzymes (acetylcholinesterase and monoamine oxidase) were determined along with sodium-potassium ATPase (Na⁺K⁺-ATPase). Plasma lipids and homeostasis model assessment of ins

SUBMITTER: Chellammal HSJ 

PROVIDER: S-EPMC9672285 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature