The neuropeptide PACAP alleviates T. gondii infection-induced neuroinflammation and neuronal impairment.

ABSTRACT:

Background

Cerebral infection with the protozoan Toxoplasma gondii (T. gondii) is responsible for inflammation of the central nervous system (CNS) contributing to subtle neuronal alterations. Albeit essential for brain parasite control, continuous microglia activation and recruitment of peripheral immune cells entail distinct neuronal impairment upon infection-induced neuroinflammation. PACAP is an endogenous neuropeptide known to inhibit inflammation and promote neuronal survival. Since PACAP is actively transported into the CNS, we aimed to assess the impact of PACAP on the T. gondii-induced neuroinflammation and subsequent effects on neuronal homeostasis.

Methods

Exogenous PACAP was administered intraperitoneally in the chronic stage of T. gondii infection, and brains wer

SUBMITTER: Figueiredo CA 

PROVIDER: S-EPMC9675261 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature