Ontology highlight
ABSTRACT:
SUBMITTER: Anthony-Gonda K
PROVIDER: S-EPMC9675454 | biostudies-literature | 2022 Nov
REPOSITORIES: biostudies-literature
Anthony-Gonda Kim K Ray Alex A Su Hang H Wang Yuge Y Xiong Ying Y Lee Danica D Block Ariele A Chilunda Vanessa V Weiselberg Jessica J Zemelko Lily L Wang Yen Y YY Kleinsorge-Block Sarah S Reese Jane S JS de Lima Marcos M Ochsenbauer Christina C Kappes John C JC Dimitrov Dimiter S DS Orentas Rimas R Deeks Steven G SG Rutishauser Rachel L RL Berman Joan W JW Goldstein Harris H Dropulić Boro B
JCI insight 20221108 21
HIV-specific chimeric antigen receptor-T cell (CAR T cell) therapies are candidates to functionally cure HIV infection in people with HIV (PWH) by eliminating reactivated HIV-infected cells derived from latently infected cells within the HIV reservoir. Paramount to translating such therapeutic candidates successfully into the clinic will require anti-HIV CAR T cells to localize to lymphoid tissues in the body and eliminate reactivated HIV-infected cells such as CD4+ T cells and monocytes/macroph ...[more]