A novel pentavalent vaccine candidate completely protects against Acinetobacter baumannii in a mouse model of peritonitis.

ABSTRACT: Acinetobacter baumannii is considered as one of the most virulent and infectious organisms that have an increased ability to both evade host immune response and resist various classes of antibiotics, leading to life-threatening infections. Multiple virulence factors have been implicated in the high prevalence rate of A. baumannii in hospitalized and immunocompromised patients. Moreover, improper use of antibiotics has led to the emergence of extensive drug-resistant strains that urgently require alternative strategies to control this superbug. Unfortunately, the availability of a licensed vaccine against A. baumannii infections is still challenged by the vast diversity among A. baumannii strains. Here, we report the development of a novel pentavalent vaccine candidate composed of two recom

SUBMITTER: Hagag YA 

PROVIDER: S-EPMC9676856 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature