Hypertonic saline for traumatic brain injury: a systematic review and meta-analysis.

ABSTRACT:

Background

Traumatic brain injury (TBI) causes mortality and long-term disability among young adults and imposes a notable cost on the healthcare system. In addition to the first physical hit, secondary injury, which is associated with increased intracranial pressure (ICP), is defined as biochemical, cellular, and physiological changes after the physical injury. Mannitol and Hypertonic saline (HTS) are the treatment bases for elevated ICP in TBI. This systematic review and meta-analysis evaluates the effectiveness of HTS in the management of patients with TBI.

Methods

This study was conducted following the Joanna Briggs Institute (JBI) methods and PRISMA statement. A systematic search was performed through six databases in February 2022, to find studies that evaluated the ef

SUBMITTER: Gharizadeh N 

PROVIDER: S-EPMC9677698 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature