Early Hyperchloremia and Outcomes After Severe Traumatic Brain Injury: Analysis of Resuscitation Outcomes Consortium Hypertonic Saline Trial.

ABSTRACT: To investigate the effect of the occurrence of early hyperchloremia on death or severe disability at 180 days in patients with severe traumatic brain injury (TBI).

Design

Post hoc analysis of Resuscitation Outcomes Consortium Hypertonic Saline (ROC HS)-TBI trial.

Setting

A total of 114 North American emergency medical services agencies in the ROC.

Patients

A total of 991 patients with severe TBI and Glasgow Coma Scale score of less than or equal to 8.

Interventions

Prehospital resuscitation with single IV dose (250 cc) of 7.5% saline in 6% dextran-70, 7.5% saline (no dextran), or crystalloid.

Measurements and main results

Patients with increased serum chloride concentrations (110 mmol/L or greater) 24 hours after randomization were identified. Hyperchlore

SUBMITTER: Qureshi AI 

PROVIDER: S-EPMC9726372 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature