Functional role of CD40 and CD154 costimulatory signals in IgZ-mediated immunity against bacterial infection.

ABSTRACT: CD40 and CD154 are one of the best-characterized costimulatory molecules essential for adaptive immunity, which extensively involved in T and B cell activation, IgM Ab production, isotype class switching, germinal center formation and affinity maturation. However, the functionality of CD40 and CD154 in IgZ-mediated immunity remains limited. In this study, we explored the regulatory role of Cd40-Cd154 interaction in IgZ-mediated antibacterial immunity in zebrafish. The results showed that the IgZ-mediated antibacterial response can be significantly induced in response to A. hydrophila infection. The percentage of Cd40⁺IgZ⁺ B cells and the production of IgZ Ab were substantially increased upon A. hydrophila stimulation, but these reactions were markedly de

SUBMITTER: Su N 

PROVIDER: S-EPMC9680072 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature