Performance of polygenic risk scores for cancer prediction in a racially diverse academic biobank.

ABSTRACT:

Purpose

Genome-wide association studies have identified hundreds of single nucleotide variations (formerly single nucleotide polymorphisms) associated with several cancers, but the predictive ability of polygenic risk scores (PRSs) is unclear, especially among non-Whites.

Methods

PRSs were derived from genome-wide significant single-nucleotide variations for 15 cancers in 20,079 individuals in an academic biobank. We evaluated the improvement in discriminatory accuracy by including cancer-specific PRS in patients of genetically-determined African and European ancestry.

Results

Among the individuals of European genetic ancestry, PRSs for breast, colon, melanoma, and prostate were significantly associated with their respective cancers. Among the individuals of African g

SUBMITTER: Wang L 

PROVIDER: S-EPMC9680700 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature