Pilot Study: PARP1 Imaging in Advanced Prostate Cancer.

ABSTRACT:

Purpose

PARP inhibitor (PARPi) therapy is approved for patients with metastatic castration-resistant prostate cancer (mCRPC) and homologous recombination repair (HRR) genomic aberrations. However, only a fraction of patients with BRCA1/2 mutations respond to PARPi therapy. In this pilot study, we assess PARP-1 expression in prostate cancer patients with and without HRR genomic alternations using a novel PARP-based imaging agent.

Procedures

Nine advanced prostate cancer patients were studied with PET/CT and [¹⁸F]FluorThanatrace (FTT), an analogue of the PARPi rucaparib. Images were analyzed using maximum standardized uptake values (SUV_max). PARP expression was assessed by immunohistochemistry (IHC) when feasible (n = 4).

Results

We found great var

SUBMITTER: Dehdashti F 

PROVIDER: S-EPMC9681698 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature