A Pilot Study of Dynamic ¹⁸F-DCFPyL PET/CT Imaging of Prostate Adenocarcinoma in High-Risk Primary Prostate Cancer Patients.

ABSTRACT:

Purpose

The primary aim of this study was to investigate the pharmacokinetics of ¹⁸F-DCFPyL, an ¹⁸F-labeled PSMA-based ligand, and to explore the utility of early time point positron emission tomography (PET) imaging extracted from PET data to distinguish malignant primary prostate from benign prostate tissue.

Procedures

Ten consecutive patients with biopsy-proven high-risk prostate cancer underwent a dynamic ¹⁸F-DCFPyL PET/CT scan of the pelvis for the first 45 min post-injection (p.i.) followed by a static PET/CT at 2 h p.i. ¹⁸F-DCFPyL uptake values and kinetics were compared between benign prostate tissue and prostate cancer, including quantitative pharmacokinetic PET parameters extracted from ¹⁸F-DCFPyL time activity

SUBMITTER: Lu M 

PROVIDER: S-EPMC10572101 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature