Identification of Platinum(II) Sulfide Complexes Suitable as Intramuscular Cyanide Countermeasures.

ABSTRACT: The development of rapidly acting cyanide countermeasures using intramuscular injection (IM) represents an unmet medical need to mitigate toxicant exposures in mass casualty settings. Previous work established that cisplatin and other platinum(II) or platinum(IV)-based agents effectively mitigate cyanide toxicity in zebrafish. Cyanide's in vivo reaction with platinum-containing materials was proposed to reduce the risk of acute toxicities. However, cyanide antidote activity depended on a formulation of platinum-chloride salts with dimethyl sulfoxide (DMSO) followed by dilution in phosphate-buffered saline (PBS). A working hypothesis to explain the DMSO requirement is that the formation of platinum-sulfoxide complexes activates the cyanide scavenging properties of platinum. Preparati

SUBMITTER: Behymer MM 

PROVIDER: S-EPMC9682522 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature