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The role of type I IFN in autoimmune and autoinflammatory diseases with CNS involvement.

ABSTRACT: Type I interferons (IFNs) are major mediators of innate immunity, with well-known antiviral, antiproliferative, and immunomodulatory properties. A growing body of evidence suggests the involvement of type I IFNs in the pathogenesis of central nervous system (CNS) manifestations in the setting of chronic autoimmune and autoinflammatory disorders, while IFN-β has been for years, a well-established therapeutic modality for multiple sclerosis (MS). In the present review, we summarize the current evidence on the mechanisms of type I IFN production by CNS cellular populations as well as its local effects on the CNS. Additionally, the beneficial effects of IFN-β in the pathophysiology of MS are discussed, along with the contributory role of type I IFNs in the pathogenesis of neuropsychiatric lupus erythematosus and type I interferonopathies.

SUBMITTER: Raftopoulou S

PROVIDER: S-EPMC9685560 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature

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The role of type I IFN in autoimmune and autoinflammatory diseases with CNS involvement.

Raftopoulou Sylvia S Rapti Anna A Karathanasis Dimitris D Evangelopoulos Maria Eleftheria ME Mavragani Clio P CP

Frontiers in neurology 20221110

Type I interferons (IFNs) are major mediators of innate immunity, with well-known antiviral, antiproliferative, and immunomodulatory properties. A growing body of evidence suggests the involvement of type I IFNs in the pathogenesis of central nervous system (CNS) manifestations in the setting of chronic autoimmune and autoinflammatory disorders, while IFN-β has been for years, a well-established therapeutic modality for multiple sclerosis (MS). In the present review, we summarize the current evi ...[more]

PMID: 36438941

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