Interaction of Atomically Precise Thiolated Copper Nanoclusters with Proteins: A Comparative Study.

ABSTRACT: A facile synthesis of glutathione-stabilized copper nanoclusters (CuNCs) is carried out in H₂O/ tetrahydrofuran medium. The photophysical and morphological studies performed with as-synthesized CuNCs revealed the formation of green-emissive, stable, and smaller nanoclusters. The precise composition of these as-synthesized CuNCs was predicted with the aid of electrospray ionization mass spectrometry analysis as Cu₁₂(SG)₉. Furthermore, the systematic studies of the interaction of synthesized CuNCs with three plasmatic proteins, namely, bovine serum albumin (BSA), lysozyme (Lys), and hemoglobin (Hb) have been performed by using a series of spectroscopic studies. The conformational changes in these proteins upon interacting with CuNCs and their binding stoichio

SUBMITTER: Packirisamy V 

PROVIDER: S-EPMC9685744 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature