Dataset Information

Risk Factors and Outcomes for Multidrug Resistant Pseudomonas aeruginosa Infection in Immunocompromised Patients.

ABSTRACT:

Background

Pseudomonas aeruginosa (PSA) infection often occurs in immunocompromised patients, which also face an increased risk of multidrug-resistant (MDR) bacteria. A deeper knowledge of the risk factors for MDR-PSA infection in this patient population may help to choose appropriate empirical antibiotic therapy.

Methods

a single-center case-control (1:2) retrospective study that included 48 patients with underlying immunosuppression developing MDR-PSA infection (cases) and 96 patients also immunocompromised that were infected with non-MDR-PSA (controls) was conducted. Both groups were matched by site of infection, clinical features and type of immunosuppression. Risk factors for MDR-PSA were assessed by logistic regression. Clinical outcomes were also compared between both groups.

Results

immunosuppression was due to solid cancer in 63 (43.8%) patients, solid organ transplantation in 39 (27.1%), hematological disease in 35 (24.3%) and other causes in 7 (4.9%). Independent risk factors for MDR-PSA infection were diabetes mellitus (odds ratio [OR]: 4.74; 95% confidence interval [CI]: 1.63-13.79; p = 0.004), antibiotic therapy in the previous 3 months (OR: 5.32; 95% CI: 1.93-14.73; p = 0.001), previous MDR-PSA colonization (OR: 42.1; 95% CI: 4.49-394.8; p = 0.001) and septic shock (OR: 3.73; 95% CI: 1.36-10.21; p = 0.010). MDR-PSA cases were less likely to receive adequate empirical therapy (14 [29.2%] vs. 69 [71.9%]; p < 0.001). 30-day clinical improvement was less common in MDR-PSA cases (25 [52.1%] vs. 76 [79.2%]; p = 0.001).

Conclusions

diabetes mellitus, previous MDR-PSA colonization, prior receipt of antibiotics and septic shock acted as risk factors for developing MDR-PSA infections in immunocompromised patients, who have a poorer outcome than those infected with non-MDR-PSA strains.

SUBMITTER: Hernandez-Jimenez P

PROVIDER: S-EPMC9686626 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature

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Risk Factors and Outcomes for Multidrug Resistant <i>Pseudomonas aeruginosa</i> Infection in Immunocompromised Patients.

Hernández-Jiménez Pilar P López-Medrano Francisco F Fernández-Ruiz Mario M Silva J Tiago JT Corbella Laura L San-Juan Rafael R Lizasoain Manuel M Díaz-Regañón Jazmín J Viedma Esther E Aguado José María JM

Antibiotics (Basel, Switzerland) 20221023 11

Background: Pseudomonas aeruginosa (PSA) infection often occurs in immunocompromised patients, which also face an increased risk of multidrug-resistant (MDR) bacteria. A deeper knowledge of the risk factors for MDR-PSA infection in this patient population may help to choose appropriate empirical antibiotic therapy. Methods: a single-center case-control (1:2) retrospective study that included 48 patients with underlying immunosuppression developing MDR-PSA infection (cases) and 96 patients also i ...[more]

PMID: 36358114

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