SNP-Target Genes Interaction Perturbing the Cancer Risk in the Post-GWAS.
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ABSTRACT:
SUBMITTER: Yang W
PROVIDER: S-EPMC9688512 | biostudies-literature | 2022 Nov
REPOSITORIES: biostudies-literature
Publications
SNP-Target Genes Interaction Perturbing the Cancer Risk in the Post-GWAS.
Yang Wenmin W Zhang Te T Song Xuming X Dong Gaochao G Xu Lin L Jiang Feng F
Cancers 20221117 22
Cancer ranks as the second leading cause of death worldwide, and, being a genetic disease, it is highly heritable. Over the past few decades, genome-wide association studies (GWAS) have identified many risk-associated loci harboring hundreds of single nucleotide polymorphisms (SNPs). Some of these cancer-associated SNPs have been revealed as causal, and the functional characterization of the mechanisms underlying the cancer risk association has been illuminated in some instances. In this review, ...[more]
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