The Role of WRAP53 in Cell Homeostasis and Carcinogenesis Onset.
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ABSTRACT:
SUBMITTER: Gadelha RB
PROVIDER: S-EPMC9688736 | biostudies-literature | 2022 Nov
REPOSITORIES: biostudies-literature
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The Role of WRAP53 in Cell Homeostasis and Carcinogenesis Onset.
Gadelha Renan Brito RB Machado Caio Bezerra CB Pessoa Flávia Melo Cunha de Pinho FMCP Pantoja Laudreísa da Costa LDC Barreto Igor Valentim IV Ribeiro Rodrigo Monteiro RM de Moraes Filho Manoel Odorico MO de Moraes Maria Elisabete Amaral MEA Khayat André Salim AS Moreira-Nunes Caroline Aquino CA
Current issues in molecular biology 20221104 11
The WD repeat containing antisense to TP53 (<i>WRAP53</i>) gene codifies an antisense transcript for tumor protein p53 (<i>TP53</i>), stabilization (WRAP53α), and a functional protein (WRAP53β, WDR79, or TCAB1). The WRAP53β protein functions as a scaffolding protein that is important for telomerase localization, telomere assembly, Cajal body integrity, and DNA double-strand break repair. WRAP53β is one of many proteins known for containing WD40 domains, which are responsible for mediating a vari ...[more]
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