Self-immolative nanosensitizer for glutathione depletion- assisted sonodynamic therapy.

ABSTRACT: Background: Despite remarkable advances in sonodynamic therapy (SDT) of cancer, the low reactive oxygen species (ROS) quantum yield of the sonosensitizer remains a critical concern in glutathione (GSH)-overexpressing cancer cells. Methods: For enhanced SDT, we report hydrophilized self-immolative polymer (SIP)-decorated TiO₂ nanoparticles (HSIPT-NPs) to achieve on-demand GSH depletion and ROS generation. Results: Upon intracellular delivery of HSIPT-NPs into hydrogen peroxide-rich cancer cells, SIP is degraded through electron transfer to produce GSH-depleting quinone methide, reprogramming GSH ^high cancer cells into GSH ^low phenotype. In the presence of ultrasound, compared to conventional TiO₂ NPs, HSIPT-NPs i

SUBMITTER: Kim CH 

PROVIDER: S-EPMC9691364 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature