BmAbl1 Regulates Silk Protein Synthesis via Glutathione Metabolism in Bombyx mori.

ABSTRACT: Bombyx mori, domesticated from wild silkworms, is an economic insect that feeds on mulberry leaves and produces silk. In the current study, we demonstrated the contribution of BmAbl1 in silk protein synthesis. The inhibition and knockout of BmAbl1 can reduce the larva weight and CSW. The effect on CSW of BmAbl1 is not on the transcriptional level, but on the translational level. RNA-sequencing data suggested that amino acid synthesis and the metabolism process had a great difference between the BmAbl1^- and Control strain, particularly glutathione metabolism. An abnormality in glutathione metabolism led to the reduction of free glycine and serine content, which are the main components of fibroin protein. Finally, fibroin protein synthesis has be

SUBMITTER: Qin S 

PROVIDER: S-EPMC9696079 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature