3D-Printed EVA Devices for Antiviral Delivery and Herpes Virus Control in Genital Infection.

ABSTRACT: Herpes viruses are widespread in the human population and can cause many different diseases. Genital herpes is common and can increase the risk of HIV infection and neonatal herpes. Acyclovir is the most used drug for herpes treatment; however, it presents some disadvantages due to its poor oral bioavailability. In this study, some ethylene vinyl acetate devices with different acyclovir amounts (0, 10, and 20 wt.%) were manufactured by fused filament fabrication in two different geometries, an intrauterine device, and an intravaginal ring. Thermal analyses suggested that the crystallinity of EVA decreased up to 8% for the sample loaded with 20 wt.% of acyclovir. DSC, SEM, and FTIR analyses confirmed that the drug was successfully incorporated into the EVA matrix. Moreover, the drug release

SUBMITTER: de Carvalho Rodrigues V 

PROVIDER: S-EPMC9696101 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature