Ontology highlight
ABSTRACT:
SUBMITTER: Sun H
PROVIDER: S-EPMC9699209 | biostudies-literature | 2022 Oct
REPOSITORIES: biostudies-literature
Sun Haiwei H Wang Kai K Yao Wei W Liu Jingyi J Lv Lu L Shi Xinjin X Chen Hongjun H
Viruses 20221031 11
Influenza A virus (IAV) prevents innate immune signaling during infection. In our previous study, the production of pro-inflammatory cytokines was associated with Cullin-1 RING ligase (CRL1), which was related to NF-κB activation. However, the underlying mechanism is unclear. Here, an E3 ligase, β-transducin repeat-containing protein (β-TrCP), was significantly downregulated during IAV infection. Co-IP analysis revealed that non-structural 1 protein (NS1) interacts with β-TrCP. With co-transfect ...[more]