The effects of betamethasone on the amplitude integrated EEG of infants born at 34- or 35-weeks gestation.

ABSTRACT:

Objective

Assess if maternal betamethasone administration at 34-35 weeks accelerated neonatal amplitude integrated EEG (aEEG) maturation.

Study design

Nested, observational cohort in 7 centers participating in the Antenatal Late Preterm Steroid randomized trial. Up to 2 aEEGs were obtained in neonates born from 34⁰-35⁶ weeks gestation before 72 h (aEEG 1) and at 5-7 days (aEEG 2) if hospitalized. Personnel and aEEG central readers were masked to the intervention. The primary outcome was maturation reflected by cycle frequency; secondary outcomes were border voltage, span, and discontinuity.

Results

58 neonates were enrolled (betamethasone, 28, placebo, 30). On aEEG 1, cycle frequency did not differ, but betamethasone exposed infants had a greater

SUBMITTER: Laptook AR 

PROVIDER: S-EPMC9699898 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature