Low QRS Voltages in Cardiac Amyloidosis: Clinical Correlates and Prognostic Value.

ABSTRACT:

Background

Low QRS voltages (LQRSVs) are a common electrocardiographic feature in patients with light chain amyloidosis (AL) and transthyretin amyloidosis (ATTR) cardiac amyloidosis (CA).

Objectives

The aim of this study was to identify clinical and echocardiographic correlates of LQRSV and to investigate their prognostic significance in patients with CA.

Methods

This was a multicenter, retrospective study performed in 6 CA referral centers including consecutive patients with AL and ATTR CA. LQRSVs were defined as a QRS amplitude ≤5 mm (0.5 mV) in all peripheral leads. The study outcome was cardiovascular (CV) mortality.

Results

Overall, 411 (AL CA: n = 120, ATTR CA: n = 291) patients were included. LQRSVs were present in 66 (55%) patients with AL CA and 103 (3

SUBMITTER: Cipriani A 

PROVIDER: S-EPMC9700257 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature