Subcutaneous fat necrosis in newborns: a systematic literature review of case reports and model of pathophysiology.

ABSTRACT:

Background

Subcutaneous fat necrosis of the newborn (SCFN) is a rare disease occurring in the first days of life. Characteristically, the infants show hard nodules in subcutaneous tissue, purple or erythematous in color and appear on the upper back, cheeks, buttocks and limbs. In most cases, SCFN is a self-limiting disease, as the nodules disappear in up to 6 months. A severe complication associated with SCFN is hypercalcaemia. Pathophysiological mechanisms causing SCFN or associated hypercalcaemia are not fully understood yet.

Methods

A systematic literature research including the six biggest databases for medical research has been used to identify all published case reports of SCFN. N = 206 publications has been identified containing n = 320 case reports. All cases have be

SUBMITTER: Frank L 

PROVIDER: S-EPMC9700527 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature