Transcriptional differences between coronavirus disease 2019 and bacterial sepsis.

ABSTRACT:

Background

Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2, has led to major public health crises worldwide. Several studies have reported the comprehensive mRNA expression analysis of immune-related genes in patients with COVID-19, using blood samples, to understand its pathogenesis; however, the characteristics of RNA expression in COVID-19 and bacterial sepsis have not been compared. The current study aimed to address this gap.

Methods

RNA-sequencing and bioinformatics analyses were used to compare the transcriptome expression of whole blood samples from patients with COVID-19 and patients with sepsis who were admitted to the intensive care unit of Osaka University Graduate School of Medicine.

Results

The COVID-19 and

SUBMITTER: Ito H 

PROVIDER: S-EPMC9702864 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature