Ontology highlight
ABSTRACT:
SUBMITTER: Varyani F
PROVIDER: S-EPMC9705247 | biostudies-literature | 2022 Jun
REPOSITORIES: biostudies-literature
Varyani Fumi F Löser Stephan S Filbey Kara J KJ Harcus Yvonne Y Drurey Claire C Poveda Marta Campillo MC Rasid Orhan O White Madeleine P J MPJ Smyth Danielle J DJ Gerbe François F Jay Philippe P Maizels Rick M RM
Mucosal immunology 20220314 6
Macrophage migration inhibitory factor (MIF) is a key innate immune mediator with chemokine- and cytokine-like properties in the inflammatory pathway. While its actions on macrophages are well-studied, its effects on other cell types are less understood. Here we report that MIF is required for expansion of intestinal tuft cells during infection with the helminth Nippostrongylus brasiliensis. MIF-deficient mice show defective innate responses following infection, lacking intestinal epithelial tuf ...[more]