The causal relationship between psoriasis, psoriatic arthritis, and inflammatory bowel diseases.

ABSTRACT: Psoriasis is more common in patients with inflammatory bowel disease (IBD) than in the general population. Similarly, patients with psoriasis or psoriatic arthritis (PsA) have a higher incidence of IBD. However, whether this association is causal remains unknown. Therefore, we used a two-sample bidirectional Mendelian randomization (MR) analysis to identify this relationship. According to MR analysis, psoriasis and PsA causally increased the odds of developing Crohn's disease (OR = 1.350 (1.066-1.709) P = 0.013; OR = 1.319 (1.166-1.492) P < 0.001). In contrast, MR estimates gave little support to a possible causal effect of psoriasis, PsA, on ulcerative colitis (OR = 1.101 (0.905-1.340) P = 0.335; OR = 1.007 (0.941-1.078) P = 0.831). Similarly, the reverse analysis suggested the Crohn's di

SUBMITTER: Sun Y 

PROVIDER: S-EPMC9705442 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature