Possible Contribution of Alternative Transcript Isoforms in Mature Biofilm Growth Phase of Candida glabrata.

ABSTRACT: Expression of genome-wide alternative transcript isoforms and differential transcript isoform usage in different biological conditions (isoform switching) are responsible for the varied proteomic functional diversity in higher eukaryotic organisms. However, these mechanisms have not been studied in Candida glabrata, which is a potent eukaryotic opportunistic pathogen. Biofilm formation is an important virulence factor of C. glabrata that withstands antifungal drug stress and overcomes the host-immune response. Here, we present the genome-wide differential transcript isoform expression (DTE) and differential transcript isoform usage (DTU) in a mature biofilm growth phase of C. glabrata (clinical isolate; NCCPF 100,037) using the RNA sequencing approach. The DTE a

SUBMITTER: Raj K 

PROVIDER: S-EPMC9705674 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature