Functions of PUF Family RNA-Binding Proteins in Aspergillus nidulans.

ABSTRACT: RNA-binding proteins are involved in RNA metabolism and posttranscriptional regulation of various fundamental biological processes. The PUF family of RNA-binding proteins is highly conserved in eukaryotes, and its members regulate gene expression, mitochondrial biogenesis, and RNA processing. However, their biological functions in Aspergillus species remain mostly unknown in filamentous fungi. Here we have characterized the puf genes in the model organism Aspergillus nidulans. We generated deletion mutant strains for the five putative puf genes present in the A. nidulans genome and investigated their developmental phenotypes. Deletion of pufA or pufE affected fungal growth and asexual development. pufA mutants exhibited decreased production of asex

SUBMITTER: Son SH 

PROVIDER: S-EPMC9706018 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature