Development of Effective Siglec-9 Antibodies Against Cancer.

ABSTRACT:

Purpose of review

This study aims to review state-of-the-art advances in Siglec-9-directed antibodies and to highlight specific aspects of Siglec-9 antibodies that are suitable to mount anti-tumor immunity.

Recent findings

Controversies surrounding studies on Siglec-9 antibodies can confound future studies. In this review, we have highlighted some controversies, explained the distinction between Siglec-9 agonistic and antagonistic (endocytic) antibodies, and discussed their suitability in sustaining anti-tumor immunity. Siglec-9 is an immune checkpoint target and an immunoinhibitory receptor that can engage either sialic acid ligands or agonistic antibodies. Through Siglec-9 sialic acid interactions, activated immunoreceptor tyrosine-based inhibitory signaling of the immune

SUBMITTER: Wang JHS 

PROVIDER: S-EPMC9707166 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature