Elevated plasma D-dimer levels in patients with anti-N-methyl-D-aspartate receptor encephalitis

ABSTRACT:

Purpose

We aimed to explore the difference in coagulation function between healthy individuals and patients with anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis and its relationship with disease severity.

Methods

We retrospectively compared coagulation function in 161 patients with first-attack anti-NMDAR encephalitis and 178 healthy individuals. The association between D-dimer levels and disease severity was analyzed using binary logistic regression. Receiver operating characteristic (ROC) curves were used to analyze the predictive value of D-dimer levels for the severity of anti-NMDAR encephalitis.

Results

Compared to control individuals, patients with anti-NMDAR encephalitis had higher D-dimer levels (median 0.14 vs. 0.05 mg/L, p < 0.001), blood w

SUBMITTER:  

PROVIDER: S-EPMC9707621 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature