Attention-deficit hyperactivity disorder symptoms and brain morphology: Examining confounding bias.

ABSTRACT:

Background

Associations between attention-deficit/hyperactivity disorder (ADHD) and brain morphology have been reported, although with several inconsistencies. These may partly stem from confounding bias, which could distort associations and limit generalizability. We examined how associations between brain morphology and ADHD symptoms change with adjustments for potential confounders typically overlooked in the literature (aim 1), and for the intelligence quotient (IQ) and head motion, which are generally corrected for but play ambiguous roles (aim 2).

Methods

Participants were 10-year-old children from the Adolescent Brain Cognitive Development (N = 7722) and Generation R (N = 2531) Studies. Cortical area, volume, and thickness were measured with MRI and ADHD

SUBMITTER: Dall'Aglio L 

PROVIDER: S-EPMC9708072 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature