Dataset Information

The metabolic phenotype of the patient influences the reduction in carotid intima-media thickness achieved following metabolic surgery.

ABSTRACT:

Objectives

To determine whether metabolic phenotype is associated with the change in carotid intima-media thickness (CIMT) in patients undergoing bariatric /metabolic surgery (BMS).

Methods

We performed a case-control study of BMS candidates who had metabolically unhealthy obesity (MUO) or metabolically healthy obesity (MHO). We measured the change in CIMT during the 9 months following BMS. The plasma tumor necrosis factor-α, interleukin-1β, adiponectin, leptin, nitric oxide (NO), vascular endothelial growth factor A (VEGF-A), and malondialdehyde concentrations were determined, adipocyte area was measured histologically, and adipose tissue area was estimated using computed tomography.

Results

Fifty-six patients (mean age 44.5 years, mean body mass index 44.9 kg/m², 53% women, and 53% had MUO) were studied. Nine months following BMS, the MUO phenotype was not associated with a significant reduction in CIMT, and that of the MHO group was larger. In addition, fewer participants achieved a 10% reduction in CIMT in the MUO group. A CIMT reduction was associated with lower VEGF-A and NO in the MUO group, while that in the MHO group was associated with a higher NO concentration.

Conclusion

The metabolic phenotype of patients may influence their change in CIMT following BMS, probably through circulating vasodilatory and pro-inflammatory molecules.

SUBMITTER: Melchor-Lopez A

PROVIDER: S-EPMC9709181 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature

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Publications

The metabolic phenotype of the patient influences the reduction in carotid intima-media thickness achieved following metabolic surgery.

Melchor-López Alberto A Suárez-Cuenca Juan Antonio JA Banderas-Lares Diana Zaineff DZ De la Peña-Sosa Gustavo G Salamanca-García Moisés M Vera-Gómez Eduardo E Hernández-Patricio Alejandro A Gutiérrez-Buendía Juan Ariel JA Zamora-Alemán Carlos Ramiro CR Alcaráz-Estrada Sofía Lizeth SL Ortiz-Fernández Moisés M Montoya-Ramírez Jesús J Felipe Gaytán-Fuentes Omar O Escamilla-Tilch Mónica M Pineda-Juárez Juan Antonio JA Antonio Téllez-González Mario M Rodríguez-Arellano Martha Eunice ME Contreras-Ramos Alejandra A Hernández-Muñoz Rolando Efraín RE Gutiérrez-Salinas José J García Silvia S Mondragón-Terán Paul P

The Journal of international medical research 20221101 11

<h4>Objectives</h4>To determine whether metabolic phenotype is associated with the change in carotid intima-media thickness (CIMT) in patients undergoing bariatric /metabolic surgery (BMS).<h4>Methods</h4>We performed a case-control study of BMS candidates who had metabolically unhealthy obesity (MUO) or metabolically healthy obesity (MHO). We measured the change in CIMT during the 9 months following BMS. The plasma tumor necrosis factor-α, interleukin-1β, adiponectin, leptin, nitric oxide (NO), ...[more]

PMID: 36437534

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Project description:BackgroundIntima-media thickness of the walls of the common carotid artery and internal carotid artery may add to the Framingham risk score for predicting cardiovascular events.MethodsWe measured the mean intima-media thickness of the common carotid artery and the maximum intima-media thickness of the internal carotid artery in 2965 members of the Framingham Offspring Study cohort. Cardiovascular-disease outcomes were evaluated for an average follow-up of 7.2 years. Multivariable Cox proportional-hazards models were generated for intima-media thickness and risk factors. We evaluated the reclassification of cardiovascular disease on the basis of the 8-year Framingham risk score category (low, intermediate, or high) after adding intima-media thickness values.ResultsA total of 296 participants had a cardiovascular event. The risk factors of the Framingham risk score predicted these events, with a C statistic of 0.748 (95% confidence interval [CI], 0.719 to 0.776). The adjusted hazard ratio for cardiovascular disease with a 1-SD increase in the mean intima-media thickness of the common carotid artery was 1.13 (95% CI, 1.02 to 1.24), with a nonsignificant change in the C statistic of 0.003 (95% CI, 0.000 to 0.007); the corresponding hazard ratio for the maximum intima-media thickness of the internal carotid artery was 1.21 (95% CI, 1.13 to 1.29), with a modest increase in the C statistic of 0.009 (95% CI, 0.003 to 0.016). The net reclassification index increased significantly after addition of intima-media thickness of the internal carotid artery (7.6%, P<0.001) but not intima-media thickness of the common carotid artery (0.0%, P=0.99). With the presence of plaque, defined as intima-media thickness of the internal carotid artery of more than 1.5 mm, the net reclassification index was 7.3% (P=0.01), with an increase in the C statistic of 0.014 (95% CI, 0.003 to 0.025).ConclusionsThe maximum internal and mean common carotid-artery intima-media thicknesses both predict cardiovascular outcomes, but only the maximum intima-media thickness of (and presence of plaque in) the internal carotid artery significantly (albeit modestly) improves the classification of risk of cardiovascular disease in the Framingham Offspring Study cohort. (Funded by the National Heart, Lung, and Blood Institute.).

Dataset Information

The metabolic phenotype of the patient influences the reduction in carotid intima-media thickness achieved following metabolic surgery.

Objectives

Methods

Results

Conclusion

Publications

The metabolic phenotype of the patient influences the reduction in carotid intima-media thickness achieved following metabolic surgery.

Similar Datasets

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