Metabolomics of testosterone enanthate administration during severe-energy deficit.

ABSTRACT:

Introduction

Testosterone administration attenuates reductions in total body mass and lean mass during severe energy deficit (SED).

Objectives

This study examined the effects of testosterone administration on the serum metabolome during SED.

Methods

In a double-blind, placebo-controlled clinical trial, non-obese men were randomized to receive 200-mg testosterone enanthate/wk (TEST) (n = 24) or placebo (PLA) (n = 26) during a 28-d inpatient, severe exercise- and diet-induced energy deficit. This study consisted of three consecutive phases. Participants were free-living and provided a eucaloric diet for 14-d during Phase 1. During Phase 2, participants were admitted to an inpatient unit, randomized to receive testosterone or placebo, and underwent SED for 28-d. During P

SUBMITTER: Stein JA 

PROVIDER: S-EPMC9712311 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature