Ontology highlight
ABSTRACT:
SUBMITTER: Petric Howe M
PROVIDER: S-EPMC9712626 | biostudies-literature | 2022 Oct
REPOSITORIES: biostudies-literature
Petrić Howe Marija M Crerar Hamish H Neeves Jacob J Harley Jasmine J Tyzack Giulia E GE Klein Pierre P Ramos Andres A Patani Rickie R Luisier Raphaëlle R
Genome research 20220930 10
Intron retention (IR) is now recognized as a dominant splicing event during motor neuron (MN) development; however, the role and regulation of intron-retaining transcripts (IRTs) localized to the cytoplasm remain particularly understudied. Here we show that IR is a physiological process that is spatiotemporally regulated during MN lineage restriction and that IRTs in the cytoplasm are detected in as many as 13% (<i>n</i> = 2297) of the genes expressed during this process. We identify a major cla ...[more]