The role of gut microbial β-glucuronidase in drug disposition and development.
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ABSTRACT:
SUBMITTER: Gao S
PROVIDER: S-EPMC9717552 | biostudies-literature | 2022 Oct
REPOSITORIES: biostudies-literature
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The role of gut microbial β-glucuronidase in drug disposition and development.
Gao Song S Sun Rongjin R Singh Rashim R Yu So Sik S Chan Clement T Y CTY Savidge Tor T Hu Ming M
Drug discovery today 20220709 10
Gut microbial β-glucuronidase (gmGUS) is involved in the disposition of many endogenous and exogenous compounds. Preclinical studies have shown that inhibiting gmGUS activity affects drug disposition, resulting in reduced toxicity in the gastrointestinal tract (GIT) and enhanced systemic efficacy. Additionally, manipulating gmGUS activity is expected to be effective in preventing/treating local or systemic diseases. Although results from animal studies are promising, challenges remain in develop ...[more]
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