Association of plasma microbial composition with a leaky gut in obesity-related osteoarthritis: An exploratory study

ABSTRACT:

Objective

To examine the plasma microbiome for differences between obese individuals with and without osteoarthritis (OA) and its association with serum lipopolysaccharide (LPS).

Design

Blood samples from 70 participants with body mass index (BMI) ​≥ ​30kg/m2 and age ≥55 years, with (cases) or without (controls) hand plus knee OA, were analyzed for serum LPS and composition of the plasma microbiome. The Dirichlet-multinominal recursive partitioning model (DM-RPart) was applied to microbiome compositional data to test the hypothesis that LPS levels distinguish plasma microbiome, accounting for BMI and age.

Results

No significant differences in alpha diversity, or compositional differences between groups at the genus level, were seen between cases and controls (p ​

SUBMITTER: Arbeeva L 

PROVIDER: S-EPMC9718202 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature