The apparent interferon resistance of transmitted HIV-1 is possibly a consequence of enhanced replicative fitness.

ABSTRACT: HIV-1 transmission via sexual exposure is an inefficient process. When transmission does occur, newly infected individuals are colonized by the descendants of either a single virion or a very small number of establishing virions. These transmitted founder (TF) viruses are more interferon (IFN)-resistant than chronic control (CC) viruses present 6 months after transmission. To identify the specific molecular defences that make CC viruses more susceptible to the IFN-induced 'antiviral state', we established a single pair of fluorescent TF and CC viruses and used arrayed interferon-stimulated gene (ISG) expression screening to identify candidate antiviral effectors. However, we observed a relatively uniform ISG resistance of transmitted HIV-1, and this directed us to investigate possible unde

SUBMITTER: Sugrue E 

PROVIDER: S-EPMC9718408 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature