Repression of the iron exporter ferroportin may contribute to hepatocyte iron overload in individuals with type 2 diabetes.

ABSTRACT:

Objective

Hyperferremia and hyperferritinemia are observed in patients and disease models of type 2 diabetes mellitus (T2DM). Likewise, patients with genetic iron overload diseases develop diabetes, suggesting a tight link between iron metabolism and diabetes. The liver controls systemic iron homeostasis and is a central organ for T2DM. Here, we investigate how the control of iron metabolism in hepatocytes is affected by T2DM.

Methods

Perls Prussian blue staining was applied to analyze iron distribution in liver biopsies of T2DM patients. To identify molecular mechanisms underlying hepatocyte iron accumulation we established cellular models of insulin resistance by treatment with palmitate and insulin.

Results

We show that a subset of T2DM patients accumulates iron in

SUBMITTER: Qiu R 

PROVIDER: S-EPMC9719871 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature