Role of biomarkers (sFlt-1/PlGF) in cases of COVID-19 for distinguishing preeclampsia and guiding clinical management.

ABSTRACT:

Objectives

To analyze soluble fms-like tyrosine kinase 1 (sFlt-1) and placental growth factors (PlGF) concentrations and their ratio in pregnant and postpartum women with suspected COVID-19, and further investigate conditions associated with an increased ratio (sFlt-1/PlGF > 38), including preeclampsia (PE) and severe acute respiratory syndrome (SARS).

Study design

The present study is a secondary analysis of a prospective cohort. Blood samples were collected at time of COVID-19 investigation and the serum measurements of sFlt-1 and PlGF were performed. Clinical background, SARS-CoV-2 infection characteristics, maternal and perinatal outcomes were further analyzed.

Main outcome measures

Serum measurements of sFlt-1 and PlGF; obstetrics and clinical outcomes.

Result

SUBMITTER: Nobrega GM 

PROVIDER: S-EPMC9719935 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature